John Lipscomb, PhD to Present Risk Assessment Seminar
John Lipscomb, PhD, DABT, ATS, a senior toxicologist for CTEH, LLC, will present an invited virtual lecture, “Thresholds and Their Definition,” on Thursday, April 22 at 11:00 A.M. EDT. The lecture is part of the eLearning Virtual Seminar series hosted by the American College of Toxicology. In the lecture, Dr. Lipscomb will describe and discuss the process of developing human exposure standards or guidance on the basis of biological changes observed in animals.
Technical concepts from risk assessment will be discussed, including critical effect, response level, benchmark dose, point of departure, duration adjustment, human equivalent doses, dose extrapolation, physiologically based pharmacokinetic modeling, and uncertainty factors relative to the three fundamental activities of:
- Determining which effect (type of change) to choose as the basis for exposure guidance,
- Deciding the level of expression of the effect (magnitude of change) to protect against, and
- Considerations necessary when extrapolating animal experimental doses to human exposure.